Laboratory of Experimental Surgery and Surgical Research
Established by Presidential Decree 459/1987 (Government Gazette 215/8-12-1987).
Ministerial Installation Decision: Υ4α/29261/03 (Government Gazette 750/11-6-2003).
Ministerial Renaming Decision: Β1/12642/31-1-2007 (Government Gazette 235/26-2-2007).
Breeding establishment code: EL71BIO br1
User establishment code: EL71BIOexp1
Internal Rules of Procedure: Ministerial Decision Β1/12642/31-1-2007 (Government Gazette 235/26-2-2007).
Laboratory / Clinic
Laboratory of Experimental Surgery and Surgical Research
Brief Description
The Laboratory of Experimental Surgery and Surgical Research is a licensed breeding and user establishment for laboratory animals. Its staff includes 2 Faculty members (DEP), one member of the Laboratory Teaching Staff (EDIP), and a shared animal caretaker. The Laboratory carries out both educational and research work. The educational work involves: a) at the undergraduate level, the teaching of 3 elective courses and the practical training of students in subjects related to the academic fields of “Experimental Surgery” and “Laboratory Animal Science,” and b) at the postgraduate level, the training of students in surgical techniques etc., within the framework of postgraduate programs. The research work involves the execution of research protocols on animal models: a) at the undergraduate level, for the completion of diploma theses, and b) at the postgraduate level, within the framework of research projects, experimental master’s theses, and experimental doctoral (PhD) dissertations.
Faculty Members (DEP)
Director: Petros Ypsilantis, Professor of Experimental Surgery – Laboratory Animal Science
Contact Details: +30 25510 30404 (ext. 77404)
Email: pipsil@med.duth.gr
Panagoula Economou, Assistant Professor of Experimental Surgery
Email: paoikono@med.duth.gr
Laboratory Teaching Staff (EDIP)
Foteini Papachristou, Molecular Biologist, PhD
Education
A. Undergraduate Level
Elective Courses:
-
- “Experimental Surgery” (DUTH Department of Medicine)
- “Laboratory Animal Science” (DUTH Department of Medicine)
- “Principles of Laboratory Animal Management” (DUTH Department of Molecular Biology and Genetics)
B. Postgraduate Level
Workshops within the framework of Postgraduate Programs of Study
Research
- Laparoscopic surgery
- Radiofrequency-assisted liver ablation
- Radiofrequency-assisted partial hepatectomy
- Modern methods of pregnancy diagnosis in laboratory animals
- Effect of diseases and probiotic bacteria on the intestinal microbiome
- Liver regeneration
- Ischemia / reperfusion of the liver and intestine
- Effect of substances on the induction of genetic damage and cell death
Selected Publications:
- Ypsilantis P, Lambropoulou M, Karayiannakis A, Zacharoulis D, Passos I, Smyrlis C, Charisis C, Ypsilantis K, Pitiakoudis M. Gut Barrier Disruption Secondary to Radiofrequency-Assisted Liver Parenchyma Resection in a Porcine Model. J Gastrointest Surg 2022 Sep;26(9):1881-1889.
- Ypsilantis P, Lambropoulou M, Anagnostopoulos K, Kiroplastis K, Tepelopoulos G, Bangeas P, Ypsilantou I, Pitiakoudis M. Gut barrier disruption following laparoscopic versus open major liver resection in the rat. Surgery 2022; 171(4): 973-979.
- Ypsilantis P, Souftas V, Vyza V, Vraila M, Chatzaki M, Ypsilantou I, Pitiakoudis M. Magnetic resonance imaging for early pregnancy diagnosis in the laboratory rat. Lab Anim 2021; 55(3): 262-9.
- Papachristou F., Anninou N, Koukoulis G, Paraskakis S, Sertaridou E, Tsalikidis C, Pitiakoudis M, Simopoulos C, Tsaroucha A. Differential effects of cisplatin combined with the flavonoid apigenin on HepG2, Hep3B, and Huh7 liver cancer cell lines. Mutat Res Genet Toxicol Environ Mutagen. 2021; 866:503352.
- Ypsilantis P, Lambropoulou M, Anagnostopoulos K, Panidou-Tsoulou E, Ioannidis O, Totsi A, Pitiakoudis M, Simopoulos C. Effect of laparoscopic liver resection versus the open technique on hepatocyte regenerating activity in the rat. Surg Endosc 2020;24: 4812-4817
- Ypsilantis P, Lambropoulou M, Evagellou A, Papadopoulos N, Simopoulos C. Immune and inflammatory responses of the intestinal mucosa following extended liver radiofrequency ablation. Gastroent Res Pract 2017;2017:3450635.
- Ypsilantis P, Simopoulos C. A laparoscopic technique of partial hepatectomy in the rat. J Surg Res 2016; 205(2): 286-91.
- Ypsilantis P, Lambropoulou M, Kourkoutas I, Pechlivanis A, Simopoulos C. Liver radiofrequency ablation compromises the biological gut barrier. Hum Exp Toxicol 2014;33(1):64-73.
Contact Information
Laboratory of Experimental Surgery and Surgical Research
University General Hospital of Alexandroupolis
Dragana
68100 Alexandroupoli, Greece
Tel.: +30 25510 30404
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